Diabetes in dogs may indicate elevated risk of type 2 diabetes in their owners

These novel findings, from a register-based study conducted at Uppsala University in collaboration with three other universities, have now been published in The BMJ.

Previous studies have reported a possible association between adiposity in dog owners and their dogs. But could there also be a shared risk of diabetes for pet owners and their dogs and cats? Researchers at Uppsala University, the Swedish University of Agricultural Sciences, Karolinska Institutet and the University of Liverpool have now together investigated this matter in a large cohort study.

Combining a Swedish veterinary insurance register with Swedish population and health registers, the researchers could extract information on pet owners residing in Sweden. More than 175,000 dog owners and nearly 90,000 cat owners and their dogs and cats were included in the study.

The dog and cat owners were all middle-aged or older at the start of the study, and were followed up to six years. The researchers then analysed the incidence of type 2 diabetes in the pet owners and of canine and feline diabetes in the dogs and cats.

The main finding was that compared with owning a dog without diabetes, owning a dog with diabetes was associated with a 38% increased risk of type 2 diabetes. No such shared risk of diabetes could be detected in cat owners and their cats. The elevated risk for dog owners could not be explained by the age, sex, or socioeconomic circumstances of the owners, or by the age, sex, or breed of the dogs.

“Our results indicate that a dog with diabetes in the household might signal an increased risk of the dog owner developing type 2 diabetes as well. We have not had access to information about household lifestyle behaviours, but we think the association might be due to shared physical activity patterns and possibly also shared dietary habits as well as shared risk of adiposity.

If shared exercise habits are indeed a key factor, it might further help explain why we don’t see any shared diabetes risk in cat owners and their cats,” says Beatrice Kennedy, a postdoctoral research fellow in medical epidemiology at Uppsala University, one of the senior authors of the study.

Canine diabetes generally requires lifelong insulin therapy. Diabetes is more commonly diagnosed in older dogs, and in females that have not been spayed (castrated) during their prolonged dioestrus phase. Diabetes in female dogs has also been linked to overweight, and occurs more often in some Swedish hunting dog breeds.

The frequency of spaying and relative popularity of different breeds vary across countries, and the shared diabetes risk observed in this study may therefore not be applicable to other parts of the world with different dog ownership practices.

“Humans and dogs have lived together for at least 15,000 years, and continue to share their everyday lives for better or worse. In this unique study, we show that there might be common lifestyle and environmental factors that influence the risk of diabetes in the household, both in the dogs and in their owners,” comments Tove Fall, Professor of Molecular Epidemiology at Uppsala University, the other senior author of the study.

This project received financial support from the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), the Agria and Swedish Kennel Club Research Foundation, and the Göran Gustafsson Foundation. Professor Tove Fall is also holder of a European Research Council starting grant.

Publikation

Rachel Ann Delicano et al. (2020) The shared risk of diabetes between dog and cat owners and their pets: register based cohort study. BMJ. In press. DOI: 10.1136/bmj.m4337